Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases

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Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases

Background Follistatin (Fst) promotes brown adipocyte characteristics in adipose tissues. Methods Abdominal fat volume (CT scan), glucose clearance (GTT test), and metabolomics analysis (mass spectrometry) of adipose tissues from Fst transgenic (Fst-Tg) and wild type (WT) control mice were analyzed. Oxygen consumption (Seahorse Analyzer) and lipidomics (gas chromatography) was analyzed in 3T3...

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ژورنال

عنوان ژورنال: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

سال: 2018

ISSN: 1178-7007

DOI: 10.2147/dmso.s159315